The 1950s was the era when anti-depressant medications become public. Using special techniques like talk therapy and relaxation. However, medication was the best solution to cope with depression. Cannabidiol (CBD), or Cannabis products, Is a tool in the fight against depression. It is now a key area of interest for consumers and researchers alike.
Research overview on CBD:
A number of studies on animals have found that CBD has a great psychiatric potential that offers anti-depression and anti-anxiety benefits. This is because CBD influences serotonin 1A receptors. Depression is producing when there are deficiencies in the endocannabinoid system. Cannabinoid receptor is the ideal target for developing new pharmacotherapy options for both anxiety and mood disorders.
The studies of CBD helping Depression:
A study conducted in 2018 found that the medication available to treat depression and anxiety is inefficient. The basic goal of the study was to check if CBD oil helped treat depression. The study observed the antidepressant effect within 30 minutes after taking just one dose.
Conducting a study on mice in 2018 observed the antidepressant effects of CBD. The research proves that CBD helps in improving the symptoms of depression.
Opinion of experts on CBD:
Dr. Bonni Goldstein is a medical director of California-based Canna-Centers and a subject matter adviser for Weedmaps said. “Preclinical animal data reports that CBD can have antidepressant effects. There are many anecdotal reports of patients using CBD oil for depression. However, clinical trials in humans are lacking,” said Goldstein, who is also the author of “Cannabis Revealed.”
“For example, a middle aged man taking antidepressants finding the side effects to be unbearable. Furthermore, experiencing insomnia and decreased sexual function, started using low doses of a 4:1 CBD: THC tincture. He self-reported a 90% improvement of his depression symptoms with no side effects,” she said.
“There is scientific evidence to suggest that CBD has antidepressant-like effects,” Rosalia Yoon. She has a PhD, a Research Scientist for Apollo Cannabis Clinics in Ontario, Canada, told Weedmaps. “From a neurophysiological perspective. The endocannabinoid system (ECS) is known to modulate functions. Basically, with cognition, mood, sleep, pain, reward, and motivation. However, decreased ECS activity postulates to account for some of the symptomatology associated with depression. Things like low mood, anhedonia, anxiety, and decreased pain tolerance.”
Diving even deeper:
“Most of the evidence on the mood regulatory effects of CBD comes from pre-clinical studies. Demonstrating CBD in an exert dose-dependent with antidepressant-like effects in animal models of depression in various rodent species,”. “Of note, CBD appears to exert acute antidepressant effects. Furthermore, suggesting it may confer temporal advantages over standard antidepressant medications. The onset of action typically occurs 6-8 weeks after initiation of treatment. In brief, research on a single dose of CBD has effects lasting up to one week in rodents, suggesting sustained antidepressant effects.”
Yoon further said, “Admittedly, evidence on the antidepressant effects of CBD in humans remains inconclusive due to a scarcity of randomized, controlled trials, and the evidence comes mostly from anecdotal accounts or evaluation of depression as a secondary measure,” Yoon said.
“Considerably we are needing to conduct more human studies to understand the benefits of Cannabis products helping with depression. Nevertheless, given the positive pre-clinical evidence and the high safety index of cannabis, CBD holds promise as a therapeutic aid in managing depressive symptomatology. It should be noted that drug-drug interactions and issues of tolerability and safety with long-term use are not yet fully understood. As such, CBD is taken with care under the care and guidance of a medical doctor. especially when it pertains to the management of mood disorders,” she said.
Conclusion: To conclude, a number of patients started reporting relief with CBD treatment. Cannabis products treat depression. Studies on animals show that CBD has an antidepressant effect. However, clinical trials to support this narrative are imminent.
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